Director
Dr. Francisco Capani - Investigador Independiente CONICET

Integrantes

Investigador Asociado: Prof. Dr. Santiago Pérez Lloret
Investigador Asistente: Dr. Juan Pablo Luaces
Investigador Emérito Prof. Dr. Roberto Sica

Becarios doctorales
Magister Rodolfo Kolliker - Profesional Principal
Médica Cecilia Quarracino
Lic. Tamara Logica Tornatore
Lic. María Inés Herrera
Lic. Sonia Molina
Lic. Nicolás Toro
Médica Vanesa Cosentino
Médica Sabrina Carmona

Personal de Apoyo
Carlos Federico Kusnier - Profesional Adjunto
Lucas Udovin - Profesional Asistente

Pasantes
Silvia Zelaquett
Bianca Rosetti
TaliKorenvais

Líneas de Investigación

Cambios dinámicos en el citoesqueleto de actina sináptico inducido por la hipoxia.
Rol de las tiorredoxinas sobre el daño neuronal inducido por un proceso hipóxico.
Efecto neuroprotector del estradiol en un modelo experimantal de asfixia en ratas.
Marcadores biológicos temprano no invasivos de inflamación vascular en la aterogénesis asociada a la Artritis Psoriásica
Financiamiento

BMBF-MINCYT, Los Cambios Del Estado Redox Celular Luego De Una Asfixia Perinatal, Sobre Distintas Proteinas Involucradas En El Insulto Hipoxico Isquemico y su Efecto Sobre El Destino Celularproyecto en colaboración con el laboratorio Dr Lillig, Universidad de Greifwald, Alemania 2013-2105.

Colciencias-MINCYT, Mecanismos Moleculares del Tratamiento con estrógenos y moduladores selectivos de los receptores de estrógenos en el hipocampo de ratas sometidas a asfixia perinatal: estudios in vivo, in vitro e in silico, proyecto en colaboración con el laboratorio Dr Barreto, Universidad Javeriana de Colombia. 2013-2015.

Fundación Marató, España, 2011-2014. Evaluation of actylethanolamide-based neuroprotectants in animal models of perinatal and adult brain hypoxia. Co Investigador Principal.

UBACYT, 2011-2014 Marcadores biológicos temprano no invasivos de inflamación vascular en la aterogénesis asociada a la Artritis Psoriásica. Director.

Trabajos de los últimos dos años en publicaciones científicas

Herrera MI, Otero-Losada M, Udovin LD, Kusnier C, Kölliker-Frers R, de Souza W, ¿Capani F Could Perinatal Asphyxia Induce a Synaptopathy?New Highlights from an Experimental Model. Neural Plast. 2017:3436943. doi: 0.1155/2017/3436943. Epub 2017 Feb 23. Review.

Saraceno GE, Caceres LG, Guelman LR, Castilla R, Udovin LD, Ellisman MH, Brocco MA, Capani F Consequences of excessive plasticity in the hippocampus induced by perinatal asphyxia. Exp Neurol. 2016 286:116-123. doi: 10.1016/j.expneurol.2016.08.017.

Kolliker-Frers RA, Insua I, Razzitte G, Capani F. Chagas disease prevalence in pregnant women: migration and risk of congenital transmission. J Infect Dev Ctries. 2016. 30;10(9):895-901. doi: 10.3855/jidc.7118.

Capani F, Quarracino C, Caccuri R, Sica RE Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System. Front Aging Neurosci. 2016; 8:45. Doi: 10.3389/fnagi.2016.00045. ECollection 2016.

Sica RE, Caccuri R, Quarracino C, Capani F. Are astrocytes executive cells within the central nervous system? Arq Neuropsiquiatr. 2016 Aug;74(8):671-678. doi: 10.1590/0004-282X20160101.

Logica T, Riviere S, Holubiec MI, Castilla R, Barreto GE, Capani F. Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons. Front Aging Neurosci. 2016; 8:116. doi: 10.3389/fnagi.2016.00116. eCollection 2016. Review.

Herrera MI, Kölliker-Frers R, Barreto G, Blanco E, Capani F. Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration. Front Aging Neurosci. 2016 Apr 26; 8:81. doi: 10.3389/fnagi.2016.00081. eCollection 2016. Review.

Santos G, Giraldez-Alvarez LD, Ávila-Rodriguez M, Capani F, Galembeck E, Neto AG, Barreto GE, Andrade B SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci. 2016.8:97. doi: 10.3389/fnagi.2016.00097. eCollection 2016.

Capani F, Logica Tornatore T, Blanco E, Herrera MI, Kolliker R and Barreto G The Thioredoxins Protein System: a Key Target in Perinatal Asphyxia. Journal of Advanced Neuroscience Research, 2016, 3, 9-18

Jurado-Coronel JC, Avila-Rodriguez M, Capani F, Gonzalez J, Moran VE, Barreto GE. Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's disease. Curr Pharm Des. 2016; 22(10):1305-11. PMID: 26972289

Molina SJ, Capani F, Guelman LR. Noise exposure of immature rats can induce different age-dependent extra-auditory alterations that can be partially restored by rearing animals in an enriched environment. Brain Res. 2016. Pii: S0006-8993(16)30027-0. Doi: 10.1016/j.brainres.2016.01.050.

Merlo S, Spampinato SF, Capani F, Sortino MA. Early ß-Amyloid-induced Synaptic Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures. Curr Alzheimer Res. 2016;13(6):631-40

Blanco E, Galeano P, Holubiec MI, Romero JI, Logica T, Rivera P, Pavón FJ, Suarez J, Capani F, Rodríguez de Fonseca F. Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats. Front Neuroanat. 2015 Nov 3; 9:141. Doi: 10.3389/fnana.2015.00141. ECollection 2015.

Campanille V, Saraceno GE, Rivière S, Logica T, Kölliker R, Capani F, Castilla R. Long lasting cerebellar alterations after perinatal asphyxia in rats. Brain Res Bull. 2015 Jun 24; 116:57-66. Doi: 10.1016/j.brainresbull.2015.06.003. [Epub ahead of print]

Kolliker Frers R A, Bisoendial R J, Montoya S F, Tak P P, Capani F (2015) Psoriasis and cardiovascular risk: Immune-mediated crosstalk between metabolic, vascular and autoimmune inflammation. DOI: doi.org/10.1016/j.ijcme.2015.01.005

Otero-Losada M, Cao G, González J, Muller A, Ottaviano G, Lillig C, Capani F, Ambrosio G, Milei J. Functional and Morphological Changes in Endocrine Pancreas following Cola Drink Consumption in Rats. PLoS One. 2015 Mar 19; 10(3): e0118700. Doi: 10.1371/journal.pone.0118700. ECollection 2015.

Romero JI, Hanschmann EM, Gellert M, Eitner S, Holubiec MI, Blanco-Calvo E, Lillig CH, Capani F. Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia. Biochim Biophys Acta. 1850(6):1274-85. doi: 10.1016/j.bbagen.2015.02.015.

Participación como invitado en simposios y conferencias

1. High-resolution correlative electron tomography to solve biological problems. SAMIC Congress, San Carlos de Bariloche, Marzo 2016. Symposium
2. Aplicaciones de la microscopia a la resolución de problemas biológicos, Universidad Nacional de Bogotá, 22 de Julio de 2015. Symposium.
3. Thioredoxins contribute with a neuroprotection in experimental perinatal asphyxia. A new therapeutical challenge CIASEM Congress, Isla Margarita, Venezuela, Octubre 2015. Symposium.

Comunicaciones a Congreso
2016
R. Kolliker, A. Ares, G. Melito, F. Capani. Recent onset Psoriatic arthritis induces early proatherogenic inflammatory signs. FEBS, Turquia, Septiembre 2016.

High-resolution correlative electron tomography to solve biological problems. SAMIC Congress, San Carlos de Bariloche, Marzo 2016. Symposium

Molina, SJ, Miceli, M, Capani, F and Guelman L Behavioral and molecular changes induced by early noise exposure using different exposure schedules. partial reversal after rearing in an enriched environment. FALAN, Buenos Aires, Septiembre 2016

María Inés Herrera, Cecilia Quarracino, Rodolfo Kolliker-Frers, Fernando Rodríguez de Fonseca, Eduardo Blanco Calvo, Francisco Capani. Neuroprotective role of Palmitoylethanolamide in a rat model of perinatal hypoxia-ischemia FALAN, Buenos Aires, Septiembre 2016.

Capani F, Herrera MI, Gonzalez A, Quarracino C, Mucci S, Kollikers­Frers, R Synaptic and glial modifications induced by perinatal asphyxia. SFN, San Diego, Noviembre 2016.

2015

Saint-Martin M, Molina SJ, Capani F, Guelman LR Enriched environment is able to counteract some of the histological alterations induced by early noise exposure. Int J Dev Neurosci. 2015 Dec;47(Pt A):124. doi: 10.1016/j.ijdevneu.2015.04.331.

Molina SJ, Saint-Martin M, Capani F, Guelman LR.Rearing immature rats in an enriched environment can prevent the behavioral alterations induced by early noise exposure. Int J Dev Neurosci. 2015 Dec;47(Pt A):80. doi: 10.1016/j.ijdevneu.2015.04.220.

Capani F, Filippo M, Tau J, Golinelli B, Kölliker Frers R. A, Villa A Neurofilament phosphoform and cytokines levels in 5 years evolution patients with RRMS as surrogate blood-markers for axonal injury and inflammation IX Congreso de la International Brain Research Organization(IBRO) 7-11 Julio Rio de Janeiro Brasil.

Capani F, Kolliker Frers R, Barreto GE, Gonzalez J, Quarracino C 1Time course modifications induced by perinatal asphyxia in rat CNS. Primera Escuela de Glia en la Universidad Javeriana de Colombia, Junio 2015.

Kolliker Frers, R, Quarracino C, Herrera Inés, Isolabella Marcos, Rouvier S, Logica Tornatore T, Holubiec M, Barreto G, Gonzalez J, Castilla R, Capani F. Perinatal asphyxia induced short and long term alterations in the rat synaptic organization and function. IX Congreso de la International Brain Research Organization (IBRO) 7-11 Julio Rio de Janeiro Brasil. IX Congreso de la International Brain Research Organization (IBRO) 7-11 Julio Rio de Janeiro Brasil.

Galeano P, Blanco E,Holubiec MI, Romero JI, Logica Tornatore T, Suarez J, Pavón F, Capani F, Rodríguez de Fonseca F Effects of perinatal asphyxia on the expression of the acylethanolamide/endocannabinoid signaling system in the hippocampus and dorsal striatum of postweaned rats. Congreso de Sociedad de Psicobiología de Oviedo, Julio 2015.
Campanille V, Saraceno GE, Rivière S, Logica T, Kölliker R, Capani F, Castilla R Chronic Cerebellar alterations caused by perinatal asphyxia. Estradiol as a possibly neuroprotective therapy. XII Congress of CIASEM, Isla Margarita, Venezuela.